In situ probing of Gram-positive bacteria with high DNA G + C content using 23S rRNA-targeted oligonucleotides

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In situ probing of gram-positive bacteria with high DNA G + C content using 23S rRNA-targeted oligonucleotides.

23S-rRNA-targeted oligonucleotide probes were designed for the phylogenetic group 'Gram-positive bacteria with high G + C content of DNA' (GPBHGC). A sequence idiosyncrasy in two adjacent base pairs in the stem of helix 69 in domain IV of the 23S rRNA is present in all hitherto analysed strains of GPBHGC. An oligonucleotide probe targeted to this region hybridized only with strains of GPBHGC an...

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ژورنال

عنوان ژورنال: Microbiology

سال: 1994

ISSN: 1350-0872,1465-2080

DOI: 10.1099/00221287-140-10-2849